Recommended adult doses for ‘high dose’ antibiotic therapy

Note: many of these agents may require adjustment with significant renal impairment. Seek ID or pharmacy advice if necessary.

Oral agents:

Amoxicillin  – 1g tds

Augmentin – use ‘boosted augmentin’ (Augmentin 625mg tds + amoxicillin 500mg tds)

Ciprofloxacin – 750mg bd

Co-trimoxazole – 1440mg bd or 960mg tds

IV agents:

Amoxicillin – 1g q6h (standard dose sufficient for ‘I’ when given IV)

Augmentin – 1.2g q8h (standard dose sufficient for ‘I’ when given IV)

Ceftazidime – 2g q8h

Cefepime – 2g q8h

Piperacillin-tazobactam (Tazocin) – 4.5g q6h